ASH1L inhibitors and methods of treatment therewith

US11147885B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Jolanta Grembecka · Ann Arbor, US
• Szymon Klossowski · Ann Arbor, US
• Jing Deng · Ann Arbor, US
• Tomasz Cierpicki · Ann Arbor, US
• Hao Li · Brookline, US
• Hongzhi Miao · Ann Arbor, US
• Trupta Purohit · Ann Arbor, US
• EunGi Kim · Ann Arbor, US

Key dates

• Filing date: Apr 21, 2020
• Grant date: Oct 19, 2021
• Expiry date: Apr 21, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y203/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are small molecules that bind to ASH1L and inhibit ASH1L activity, and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.