Patent · US Active

Resolution of racemic beta-aminosulfone compounds

US11149003B2 · kind B2 · utility

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3References

14Claims

0Family size

Assignee

Quimica Sintetica, S.A. · ES

Inventors

Giuseppe Barreca · Milano, IT
Giovanni Marras · Novara, IT
Bruno Romanò · Arcore, IT

Key dates

Filing date	Mar 28, 2018
Grant date	Oct 19, 2021
Priority date	—
Expiry date	Mar 28, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C317/28
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

It is described an industrially viable and advantageous process for the preparation of (S)-beta-aminosulfone (1) starting from the corresponding racemic compound, said (S)-beta-aminosulfone being a useful intermediate for the preparation of N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)acetamide, also known as Apremilast, the latter being suitable for use in methods of treating, preventing and/or managing psoriasis or psoriatic arthritis.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.