Compositions and methods of modulating the immune response by activating alpha protein kinase 1

US11149051B2 · kind B2 · utility

Assignee

• Shanghai Yao Yuan Biotechnology Co., Ltd. · CN

Inventors

• Tian Xu · Beijing, CN
• Cong Xu · Jingwei, CN
• Danyang Liu · Shanghai, CN
• Jieqing Fan · Shanghai, CN
• Yanfang Pan · Shanghai, CN
• Tongruei Raymond Li · Shanghai, CN
• Xiaodong Chen · Lo Wu, CN

Key dates

• Filing date: Apr 26, 2019
• Grant date: Oct 19, 2021
• Expiry date: Apr 26, 2039

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A1, A2, L1, L2, L3, Z1, Z2, W1, W2, R1, R2, R3, R4, R5, R6 and R7 are defined herein.