Clonal strains of attenuated vaccinia viruses and methods of use thereof
US11149254B2 · kind B2 · utility
4Cited by
86References
65Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 13, 2012 |
| Grant date | Oct 19, 2021 |
| Priority date | — |
| Expiry date | Apr 13, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/24143
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Clonal strains of vaccinia viruses are provided. Also provided are methods of identifying and isolating attenuated and oncolytic clonal strains from virus preparations. Modified recombinant forms of the clonal strains also are provided. The clonal strains and virus preparations can be used for diagnostic and therapeutic methods, in particular for therapy and diagnosis or monitoring treatment of proliferative disorders, including neoplastic diseases, such as, but are not limited to, solid tumors and blood cancers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.