Method for purifying and quantifying thrombin and its degradation polypeptides
US11149263B2 · kind B2 · utility
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4Claims
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Key dates
| Filing date | Dec 12, 2019 |
| Grant date | Oct 19, 2021 |
| Priority date | — |
| Expiry date | Jan 5, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/96463
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided is a method for purifying α-thrombin and for quantifying α-thrombin and its degradation polypeptides in a liquid proteinatious solution. The method employs a one-step anion exchange chromatography method. The method allows purification and/or quantification of a homogenous post-translationally modified α-thrombin. The method can also be used for purification and/or quantification of β-thrombin.
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