Use of circulating tumor cell mitotic index in cancer stratification and diagnostics
US11150245B2 · kind B2 · utility
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Key dates
| Filing date | May 26, 2016 |
| Grant date | Oct 19, 2021 |
| Priority date | — |
| Expiry date | Feb 11, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/7028
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Circulating tumor cells (CTCs) are associated with metastasis of malignant solid tumors in a patient. Presented here is evidence that CTCs exhibit cell cycle phase variability and that there is a strong correlation between the number of CTCs in a mitotic cell cycle phase and the prospects for long term survival of the subject from which the cells were obtained. Also presented herein are methods of determining the mitotic cell cycle phase of CTCs from a patient having cancer and using the information in grading malignant solid tumors and predicting the likelihood of survival of the patient.
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