Methods of treating solid tumors with CCR2 antagonists
US11154556B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jan 7, 2019 |
| Grant date | Oct 26, 2021 |
| Priority date | — |
| Expiry date | Jan 7, 2039 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure provides, inter alia, methods of treating a solid-tumor by administering an effective amount of a Chemokine Receptor 2 (CCR2) antagonist. Also provided herein are methods of reducing the number of macrophages in a solid tumor microenvironment, said method comprising administering effective amount of a Chemokine Receptor 2 (CCR2) antagonist. In an additional aspect, the current disclosure further provides methods of increasing the number CD8+ T cells in a solid tumor microenvironment, said method comprising administering effective amount of a Chemokine Receptor 2 (CCR2) antagonist. In some embodiments, the CCR2 antagonist has the formula I:
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.