Coating process for microfluidic sample arrays

US11154834B2 · kind B2 · utility

Assignee

• Life Technologies Corporation · US

Inventors

• Colin Brenan · Marblehead, US
• Jamie Cho · Stoughton, US
• Javier Garcia · València, ES
• Robert Hess · Cambridge, US
• Tanya S. Kanigan · Cambridge, US
• Arrin Katz · Cambridge, US
• Namyong Kim · Palo Alto, US
• John Linton · Lincoln, US
• Shailesh Srivastava · Medway, US
• Karl Yoder · Stoneham, US

Key dates

• Filing date: Feb 25, 2019
• Grant date: Oct 26, 2021
• Expiry date: Feb 25, 2039

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01L2300/16
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nanovolume channel having at least one interior surface in communication with the at least one exterior surface. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. Quantities related to a vector displacement from the alignment position to a fixed position on the one of the dispenser array and the microfluidic array is determined. The quantities thus determined are used to guide positioning of the dispenser array relative to the microfluidic array.