Patent · US Active

Peptide agonists and antagonists of TLR4 activation

US11155578B2 · kind B2 · utility

0Cited by

2References

10Claims

0Family size

Assignee

PEPTICOM LTD. · IL

Inventors

Amit MICHAELI · Jerusalem, IL
Immanuel LERNER · Jerusalem, IL
Anke BURGER-KENTISCHER · Stuttgart, DE
Steffen Rupp · Stuttgart, DE

Key dates

Filing date	Feb 16, 2017
Grant date	Oct 26, 2021
Priority date	—
Expiry date	Aug 3, 2037

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K2039/55516
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A group of peptides is provided which activate or inhibit toll-like receptor 4 (TLR4) and may be used to modulate inflammatory signaling and host defense pathways. The peptides were derived in silico and tested in vitro in cell cultures. These peptides may be used in the preparation of immunomodulatory compositions such as vaccine adjuvants and in pharmaceutical compositions for immunomodulation of the innate immune system such as vaccine adjuvants. The peptides may also be used in the preparation of TLR4 activators, TLR4 inhibitors and MD2 labels, e.g., for research purposes.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.