In vitro neonatal biomimetic (nMIMIC) model and methods of using same
US11156601B2 · kind B2 · utility
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Key dates
| Filing date | Sep 7, 2017 |
| Grant date | Oct 26, 2021 |
| Priority date | — |
| Expiry date | Jan 16, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/50
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
In vitro biomimetic models of the neonatal immune system are provided along with methods of using the models in pre-clinical assessment of infant immune cell-mediated and humoral responses to immunogenic stimulation, such as vaccination. The models include one comprising cord blood-derived T follicular helper cells and B cells, and one comprising cord blood-derived dendritic cells and CD4+ T cells. The models can be used, for example, to assess candidate vaccines via analysis of cellular responses to antigen and vaccine exposure.
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