Molecularly-imprinted-polymer coated conductive nanoparticles for cotinine detection, and associated devices and methods
US11156622B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 5, 2017 |
| Grant date | Oct 26, 2021 |
| Priority date | — |
| Expiry date | Feb 11, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2600/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A device for detecting cotinine includes (a) a film that includes a plurality of molecularly-imprinted-polymer (MIP) coated conductive nanoparticles having specific affinity for binding with cotinine, and (b) two electrodes in contact with the film for passing electrical current through the film to detect binding with cotinine as a change in electrical conductivity of the film. A MIP coated conductive nanoparticle for detecting cotinine includes (a) a conductive nanoparticle, (b) a silicon dioxide coating formed on the conductive nanoparticle and forming a first shell around the conductive nanoparticle, and (c) an MIP coating formed on the silicon dioxide coating and forming the second shell, wherein the MIP coating includes a polymer molecularly imprinted with cotinine to provide specific affinity for binding of cotinine to the MIP coated conductive nanoparticle such that the cotinine is detectable as a change in electrical conductivity of the MIP coated conductive nanoparticle.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.