Multi-stage sample recovery system
US11156626B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Dec 22, 2017 |
| Grant date | Oct 26, 2021 |
| Priority date | — |
| Expiry date | Apr 1, 2039 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2035/1053
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Multi-stage sample-recovery systems, including automated 2-stage and 3-stage sample-recovery systems, are provided. Such systems enable the rapid screening and recovery of samples, including viable cell-based samples, from high-throughput screening systems, including systems utilizing large-scale arrays of microcapillaries. In specific screening systems, each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules. The association of a variant protein with a molecular target is assessed by measuring a signal from the reporter element. The contents of microcapillaries identified in the assays as containing variant proteins of interest can be identified and recovered using the multi-stage systems disclosed herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.