Methods of disease activity profiling for personalized therapy management
US11160863B2 · kind B2 · utility
2Cited by
11References
20Claims
0Family size
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Key dates
| Filing date | Aug 24, 2018 |
| Grant date | Nov 2, 2021 |
| Priority date | — |
| Expiry date | Jul 5, 2039 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A90/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods for personalized therapeutic management of a disease in order to optimize therapy and/or monitor therapeutic efficacy. In particular, the present invention comprises measuring an array of one or a plurality of biomarkers at a plurality of time points over the course of therapy with a therapeutic agent to determine a mucosal healing index for selecting therapy, optimizing therapy, reducing toxicity, and/or monitoring the efficacy of therapeutic treatment. In certain instances, the therapeutic agent is a TNFα inhibitor for the treatment of a TNFα-mediated disease or disorder.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.