Thermally-cleavable protecting and linker groups
US11161869B2 · kind B2 · utility
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32Claims
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Key dates
| Filing date | Apr 12, 2018 |
| Grant date | Nov 2, 2021 |
| Priority date | — |
| Expiry date | Jul 13, 2038 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to chemical linkers and protecting groups, compounds and compositions containing the chemical linkers or protecting groups, and intermediates and processes that can be used to prepare them. The chemical linkers and protecting groups are based on pyrrolidine and piperidine activating groups, which undergo intramolecular cyclisation upon heating with release of carbon dioxide, thereby releasing the organic compound from a substrate. In particular, those chemical linkers and protecting groups are useful in the solid phase synthesis of oligonucleotides according to the following representative schemes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.