Membrane-impermeant fluorogenic chromophores
US11162951B2 · kind B2 · utility
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Key dates
| Filing date | May 18, 2018 |
| Grant date | Nov 2, 2021 |
| Priority date | — |
| Expiry date | Sep 24, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/582
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Fluorescent labeling of proteins. In particular, membrane-impermeant fluorogenic chromophores being capable of binding reversibly a functional derivative of a Photoactive Yellow Protein (PYP), or a functional fragment thereof, for fluorescently labeling biological molecules of interest, preferably proteins of interest. Especially, 4-hydroxybenzylidene-rhodanine (HBR) analogs of formula (II) as membrane-impermeant fluorogenic chromophores.
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