4-pyrazin-2-ylmethyl-morpholine derivatives and the use thereof as medicament

US11166958B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Riccardo Giovannini · Verona, IT
• Angelo Ceci · Mittelbiberach, DE
• Cornelia Dorner-Ciossek · Ingelheim am Rhein, DE
• Roland Pfau · Biberach, DE
• Dieter Wiedenmayer · Biberach an der Riß, DE

Key dates

• Filing date: Oct 16, 2019
• Grant date: Nov 9, 2021
• Expiry date: Oct 16, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K45/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are 4-pyrazin-2-ylmethyl-morpholines of formula A and pharmaceutically acceptable salts thereof, wherein R1 and R2 are defined herein. Also disclosed are processes for their preparation, pharmaceutical compositions containing the compounds, and their use in therapy, particularly in the treatment or prevention of conditions having an association with NR2B negative allosteric modulating properties.