Lipids and lipid nanoparticle formulations for delivery of nucleic acids
US11168051B2 · kind B2 · utility
13Cited by
71References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 1, 2019 |
| Grant date | Nov 9, 2021 |
| Priority date | — |
| Expiry date | Feb 1, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/113
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, G1, G2, G3, a, b, c and d are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.