Heterodimer molecule based on CH3 domain, and preparation method and use thereof
US11168149B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Dec 16, 2016 |
| Grant date | Nov 9, 2021 |
| Priority date | — |
| Expiry date | Apr 26, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/74
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The disclosure is directed to a heterodimer molecule, comprising a first polypeptide chain and a second polypeptide chain, and the first polypeptide chain comprises a first CH3 domain of an antibody heavy chain constant region, the second polypeptide chain comprises a second CH3 domain of an antibody heavy chain constant region. Comparing to a corresponding wild-type CH3 domain of a human antibody heavy chain constant region, the first CH3 domain and the second CH3 domain comprise amino acid mutations at specific positions, for example T366+K409+K392 and T366+L368+Y407+D399+F405, respectively.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.