Production of DHA and other LC PUFAs in plants

US11168332B2 · kind B2 · utility

Inventors

• Terence A. Walsh · Zionsville, US
• Daniel Gachotte · Indianapolis, US
• Ann Owens Merlo · Carmel, US
• Paul Gordon Roessler · San Diego, US
• James G. Metz · Longmont, US
• Scott Bevan · Indianapolis, US
• Jerry M. Kuner · Longmont, US

Key dates

• Filing date: Jun 2, 2020
• Grant date: Nov 9, 2021
• Expiry date: Jun 2, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/1288
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).