2-[4-(meihylaminomethyl)phenyl]-5-fluoro- benzofuran-7-carboxamide hydrochloride polymorph, preparation method therefor and application thereof

US11174237B2 · kind B2 · utility

Assignees

• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN
• FUKANG (SHANGHAI) HEALTH TECHNOLOGY CO., LTD. · CN

Inventors

• Chunhao Yang · Shanghai, CN
• Zehong Miao · Shanghai, CN
• Cun Tan · Shanghai, CN
• Xiajuan Huan · Shanghai, CN
• Jian Ding · Shanghai, CN
• Yi Chen · Shanghai, CN

Key dates

• Filing date: May 31, 2018
• Grant date: Nov 16, 2021
• Expiry date: May 31, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are a 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride polymorph, a preparation method therefor and an application thereof. Specifically, disclosed are three crystalline forms, i.e., crystalline forms A, B, and C, of 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride (formula I), preparation methods for the three crystalline forms, and use of the three crystalline forms in preparation of drugs.