Disulfide-type HMGB1-specific antibody, method for measuring disulfide-type HMGB1 and kit for said measurement, and measurement method capable of quantitating all of HMGB1 molecules including reduced HMGB1, disulfide-type HMGB1 and thrombin-cleavable HMGB1 and kit for said measurement
US11174310B2 · kind B2 · utility
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11Claims
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Key dates
| Filing date | Oct 19, 2017 |
| Grant date | Nov 16, 2021 |
| Priority date | — |
| Expiry date | Apr 28, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/52
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides antibodies that show specific reactivity to disulfide-type HMGB1. Furthermore, the present invention provides methods for specifically measuring disulfide-type HMGB1 using the antibodies, and kits or reagents for the measurement. The present invention also provides methods for measuring total HMGB1 using such an antibody and an antibody that binds to both disulfide-type HMGB1 and reduced-type HMGB1 but does not bind to des-HMGB1, and kits or reagents for the measurement.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.