Nav1.9 target polypeptide, antibody and antibody fragment combined with same, and related pharmaceutical composition
US11174312B2 · kind B2 · utility
0Cited by
0References
8Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Oct 18, 2019 |
| Grant date | Nov 16, 2021 |
| Priority date | — |
| Expiry date | Dec 7, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/76
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided is an antibody or a fragment thereof, which can be specifically bound to an S3-4 ring of a voltage sensor paddle of a domain III of voltage-gated sodium channel Nav1.9 α sub-unit, and is able to inactivate a voltage sensor valve to keep sodium ions from entering nerve cells normally. Also provided is an epitope polypeptide specifically bound to the antibody or the fragment thereof, a pharmaceutical composition comprising the antibody or the fragment thereof, and a use of the antibody or the fragment thereof in preparing a drug for treating and diseases related to pains.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.