Patent · US Active

Microfluidic model of the blood brain barrier

US11174462B2 · kind B2 · utility

1Cited by

1References

35Claims

0Family size

Assignees

EMULATE, INC. · US
Cedars Sinai Medical Center · US

Inventors

S. Jordan Kerns · Reading, US
Norman Wen · Dedham, US
Carolina Lucchesi · Westwood, US
Christopher David Hinojosa · Cambridge, US
Jacob Fraser · Somerville, US
Geraldine Hamilton · Cambridge, US
Gad Vatine · Los Angeles, US
Samuel Sanees · Santa Monica, US
Clive Svendsen · Santa Monica, US
Daniel Levner · Brookline, US
Dhruv Sareen · Deer Lake Highlands, US

Key dates

Filing date	Apr 17, 2018
Grant date	Nov 16, 2021
Priority date	—
Expiry date	Apr 17, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2539/00
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.