Application of TRPM8 protein, related peptide fragment and their antibodies
US11175289B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Nov 16, 2016 |
| Grant date | Nov 16, 2021 |
| Priority date | — |
| Expiry date | Jun 18, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/342
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A TRPM8 related peptide fragment, comprising amino acid sequence as shown in SEQ ID No: 1-18 is provided. Furthermore, application of TRPM8 protein, TRPM8 related peptide fragment and their antibodies in preparing diagnostic reagent for chronic prostatitis/chronic pelvic pain syndromes (CP/CPPS) is provided. By detecting level of TRPM8 protein molecule, TRPM8 related peptide fragment and their antibodies, the chronic prostatitis/chronic pelvic pain syndromes (CP/CPPS) is effectively diagnosed, and the present invention is capable of effectively making a distinction between CP/CPPS and other diseases of prostate. In addition, by intravenously or subcutaneously injecting 1˜30000 IU TRPM8 protein or TRPM8 related polypeptide fragments with or without combining nanoparticles for desensitization therapy, or monoclonal or polyclonal antibodies of the TRPM8 protein or polypeptide fragments, the present invention is capable of curing or significantly relieve clinical symptoms of the chronic prostatitis/chronic pelvic pain syndromes (CP/CPPS) and having an therapeutic effect.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.