Compositions comprising enzyme-cleavable amphetamine prodrugs and inhibitors thereof
US11179355B2 · kind B2 · utility
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31References
17Claims
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Key dates
| Filing date | Feb 12, 2016 |
| Grant date | Nov 23, 2021 |
| Priority date | — |
| Expiry date | Feb 12, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C279/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise an amphetamine prodrug that provides enzymatically-controlled release of amphetamine or an amphetamine analog. The composition can further comprise an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of amphetamine or the amphetamine analog from the amphetamine prodrug so as to attenuate enzymatic cleavage of the amphetamine prodrug.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.