Nanoparticle-based liver-targeting therapy and imaging
US11179474B1 · kind B1 · utility
0Cited by
3References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 25, 2016 |
| Grant date | Nov 23, 2021 |
| Priority date | — |
| Expiry date | Jan 18, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a nanoparticle comprising: a core comprising a metal and/or a semiconductor; and a plurality of ligands covalently linked to the core, wherein said ligands comprise: at least one liver-targeting ligand; at least one payload ligand comprising a bioactive agent; and at least one dilution ligand comprising a carbohydrate. Also provided are pharmaceutical compositions comprising the nanoparticles, medical uses thereof, including in the treatment and imaging of liver cancers, and processes for the production of the nanoparticles.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.