Dimethoxyphenyl substituted indole compounds as TLR7, TLR8 or TLR9 inhibitors

US11180474B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Alaric J. Dyckman · Lawrenceville, US
• Dharmpal S. Dodd · Princeton, US
• Christopher P. Mussari · Princeton, US
• Tasir Shamsul Haque · Yardley, US
• Michael A. Poss · Lawrenceville, US
• Louis J. Lombardo · Montgomery, US
• John E. Macor · Guilford, US
• Laxman Pasunoori · Warangal, IN
• Sreekantha Ratna Kumar · Bengaluru, IN

Key dates

• Filing date: Jul 27, 2017
• Grant date: Nov 23, 2021
• Expiry date: Oct 30, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D451/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R3, R4, R5, m, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.