Substituted cyanoindoline derivatives as NIK inhibitors
US11180487B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Jan 20, 2017 |
| Grant date | Nov 23, 2021 |
| Priority date | — |
| Expiry date | Oct 14, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/535
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.