Reversible modifications of nucleotides
US11180520B2 · kind B2 · utility
1Cited by
46References
6Claims
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Key dates
| Filing date | Sep 10, 2020 |
| Grant date | Nov 23, 2021 |
| Priority date | — |
| Expiry date | Sep 10, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed herein, inter alia, are methods for modifying a nucleotide, for example including reacting a nucleotide having a 3′-O-oxime moiety such as with a reagent having an —ONH2 moiety to produce a nucleotide having a 3′-O—NH2 moiety such as wherein the reagent having the —ONH2 moiety further comprises alkyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, heteroalicyclyl, aralkyl, heteroaralkyl, or (heteroalicyclyl)alkyl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.