Chimeric antigen receptor

US11180553B2 · kind B2 · utility

Assignee

• AUTOLUS LIMITED · GB

Inventors

• Shimobi Onuoha · London, GB
• Martin Pulé · London, GB
• Simon Thomas · London, GB
• Shaun Cordoba · London, GB
• Evangelia Kokalaki · London, GB

Key dates

• Filing date: Jun 15, 2017
• Grant date: Nov 23, 2021
• Expiry date: Apr 30, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/33
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a chimeric antigen receptor (CAR) which binds human CD22, having an antigen-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: CDR1—NYWIH (SEQ ID No. 1); CDR2—GINPGNNYATYRRKFQG (SEQ ID No. 2) CDR3—EGYGNYGAWFAY (SEQ ID No. 3); and b) a light chain variable region (VL) having CDRs with the following sequences: CDR1—RSSQSLANSYGNTFLS (SEQ ID No. 4); CDR2—GISNRFS (SEQ ID No. 5) CDR3—LQGTHQPYT (SEQ ID No. 6). The present invention also provides a cell comprising such a CAR and the use of such a cell to treat cancer.