Antiviral proteins and their uses in therapeutic methods

US11180758B2 · kind B2 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• David L. Thomas · San Jose, US
• Ashwin Balagopal · Columbia, US
• Ramy El-Diwany · Baltimore, US
• Robert Siliciano · Baltimore, US
• Joel Blankson · Baltimore, US
• Stuart C. Ray · Timonium, US
• Michel Anand Chattergoon · Baltimore, US
• Justin R. Bailey · Timonium, US

Key dates

• Filing date: Feb 24, 2017
• Grant date: Nov 23, 2021
• Expiry date: Jan 7, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y207/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Three proteins, BCL-G (BCL2L14), CMPK2, and LAMP3, were discovered to independently restrict HIV-1 replication both in-vivo and in-vitro. Methods are described wherein subjects are given an effective amount of a pharmaceutical composition comprising a protein selected from the group consisting of BCL-G, CMPK2, LAMP3, functional parts thereof, recombinant proteins thereof, and combinations thereof, for the purpose of treating or preventing HIV.