Patent · US Active

Methods for monitoring treatment of chronic liver disease

US11181536B2 · kind B2 · utility

1Cited by

8References

37Claims

0Family size

Assignee

The Regents of the University of Colorado, a Body Corporate · US

Inventors

Gregory Thomas Everson · Englewood, US
Steve Mark Helmke · Denver, US

Key dates

Filing date	Jul 2, 2019
Grant date	Nov 23, 2021
Priority date	—
Expiry date	Sep 29, 2039

Classification

Technology area (CPC G)Physics
CPC primaryG01N2800/085
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function test results based on hepatic blood flow. The DSI is used in methods for prediction of clinical outcomes, prediction of response to antiviral treatment, and assessment of progression of chronic liver diseases. Non-invasive methods to diagnose three distinct categories of patients with Primary Sclerosing Cholangitis (PSC) are provided. The methods can be used to diagnose PSC patients as Slow Progressors, Moderate Progressors and Rapid Progressors.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.