Method of fraction collection for a liquid chromatography system
US11185794B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 26, 2015 |
| Grant date | Nov 30, 2021 |
| Priority date | — |
| Expiry date | Aug 22, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N30/80
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
Described are a fraction collector and a method of fraction collection for a liquid chromatography system. The method includes diverting a liquid chromatography system flow from a waste channel to a collection tube at a start of a fraction collection window and collecting the system flow dispensed from the collection tube during the fraction collection window. At the end of the window, the system flow is diverted to the waste channel and a flow of a wash solvent is provided to the collection tube to dispense liquid remaining in the collection tube at the end of the window from the collection tube. The method can increase the amount of the collected fraction and can reduce or eliminate cross-contamination of a subsequently collected fraction. The method is useful for analytical scale applications where the collected fractions may have volumes defined by a limited number of drops dispensed from the collection tube.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.