Anti-CD38 antibodies and methods of use

US11186649B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Lan Wu · Bound Brook, US
• Ling Xu · Potomac, US
• Edward SEUNG · Cambridge, US
• Ronnie Wei · Weston, US
• Gary J. Nabel · Cambridge, US
• Zhi-yong Yang · Potomac, US
• Tarik Dabdoubi · Paris, FR
• Beatrice Cameron · Paris, FR
• Cendrine Lemoine · Paris, FR
• Catherine Prades · Thiais, FR

Key dates

• Filing date: Oct 9, 2018
• Grant date: Nov 30, 2021
• Expiry date: Sep 3, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/33
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure provides binding proteins that bind CD38 polypeptides, e.g., human and cynomolgus monkey CD38 polypeptides. For example, the binding proteins can be monospecific, bispecific, or trispecific binding proteins with at least one antigen binding domain that binds a CD38 polypeptide. The disclosure also provides methods for making binding proteins that bind CD38 polypeptides and uses of such binding proteins.