Isolated mammalian somatic cells containing modified RNA encoding OCT4, SOX2, and KLF4
US11186829B2 · kind B2 · utility
1Cited by
11References
11Claims
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Key dates
| Filing date | May 28, 2019 |
| Grant date | Nov 30, 2021 |
| Priority date | — |
| Expiry date | Jun 29, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are synthetic, modified RNAs for changing the phenotype of a cell, such as expressing a polypeptide or altering the developmental potential. Accordingly, provided herein are compositions, methods, and kits comprising synthetic, modified RNAs for changing the phenotype of a cell or cells. These methods, compositions, and kits comprising synthetic, modified RNAs can be used either to express a desired protein in a cell or tissue, or to change the differentiated phenotype of a cell to that of another, desired cell type.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.