Method of preparing degradable and environment responsive composite microgels
US11191728B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 14, 2020 |
| Grant date | Dec 7, 2021 |
| Priority date | — |
| Expiry date | Aug 13, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08J2367/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of preparing degradable and environment responsive composite microgels, belonging to polymer material synthesis and biomaterial technology fields. Firstly, a copolymer of L-malic acid and 6-hydroxyhexanoate is prepared; then, N,N,N′,N′-tetramethyl cystamine is prepared. The copolymer and N,N,N′,N′-tetramethyl cystamine are mixed in an organic solvent to form a mixed solution which is added into excess distilled water to produce composite microgels. The microgels have advantages of mild preparing conditions, fast reaction speed without catalysts, no impurity remained, and controllable degradation rate. The microgels can load anticancer drug doxorubicin hydrochloride, showing environment responsive controlled release due to introduction of carboxyl groups and disulfide bonds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.