Methods of treatment for bacterial infections

US11191773B2 · kind B2 · utility

Assignees

• President and Fellows of Harvard College · US
• OHIO STATE UNIVERSITY · US

Inventors

• Daniel Kahne · Brookline, US
• Michael D. Mandler · Cambridge, US
• Vadim Baidin · Cambridge, US
• Natividad Ruiz · Columbus, US

Key dates

• Filing date: Jul 16, 2018
• Grant date: Dec 7, 2021
• Expiry date: Jul 16, 2038

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention features new compositions and methods that are useful in treating a host with a Gram-negative bacterial infection. Combination therapies comprising an aminocoumarin compound and a polymyxin compound are disclosed, including certain combinations that exhibit synergistic effects. Furthermore, aminocoumarin compounds are described having altered inhibition of DNA gyrase in Gram-negative bacteria and/or the ability to target the transport proteins responsible for assembling lipopolysaccharide in the outer membrane of Gram-negative bacteria.