Process for preparing alpha-carboxamide pyrrolidine derivatives

US11192856B2 · kind B2 · utility

Assignee

• Biogen Inc. · US

Inventors

• Weirong Chen · Waltham, US
• Vinny Couming · Cambridge, US
• Erwin Irdam · Cambridge, US
• William F. Kiesman · Cambridge, US
• Daw-long Kwok · Gillette, US
• Tamera L. Mack · Cambridge, US
• Suzanne M. Opalka · Cambridge, US
• Daniel B. Patience · Arlington, US
• Donald G. Walker · Pipersville, US
• Wenli Liang · Cambridge, US

Key dates

• Filing date: Oct 5, 2018
• Grant date: Dec 7, 2021
• Expiry date: Oct 5, 2038

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a novel process for preparing a-carboxamide pyrrolidine derivatives, in particular (2S, 5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide, and to novel intermediates for use in said process along with processes for preparing said intermediates.