Patent · US Active

Crystal form of small molecule immune compound, preparation method thereof and pharmaceutical composition containing the same

US11192882B2 · kind B2 · utility

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8Claims

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Assignee

SHENZHEN NEPTUNUS PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. · CN

Inventors

Tian Tang · Tangxia, CN
Zhiying Huang · Zhejiang, CN
Jing Wu · New York, US
Yanping Chen · Boyds, US
Tao Shi · Shanghai, CN
Yanqing Wang · Jiaozuo City, CN
Jing'an Yang · Tangxia, CN

Key dates

Filing date	Jan 31, 2019
Grant date	Dec 7, 2021
Priority date	—
Expiry date	Jan 31, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/13
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Provided in the present invention are a crystal form of a small molecule immune compound, a preparation method therefor and a pharmaceutical composition containing the same; the compound is (3Z,6Z)-3-[((E)-3-(5-tert-butyl)-1H-imidazolyl-4-yl)methylene]-6-((E)-3-(3-fluorophenyl)-2-propenylene)piperazine-2,5-dione; the crystal form thereof has stable morphology, good chemical stability, high temperature resistance, and is used for treating hyperproliferative diseases. The structural formula of the compound is as shown in formula (I).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.