MDM2 protein degraders

US11192898B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Shaomeng Wang · Saline, US
• Yangbing Li · Beijing, CN
• Jiuling Yang · Ann Arbor, US
• Angelo Aguilar · Ann Arbor, US
• Bing Zhou · Ann Arbor, US
• Jiantao Hu · Ann Arbor, US
• Fuming Xu · Ypsilanti, US
• Rohan Rej · Ann Arbor, US
• Xin Han · Ann Arbor, US

Key dates

• Filing date: Apr 6, 2017
• Grant date: Dec 7, 2021
• Expiry date: Apr 6, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure provides compounds represented by Formula I-A: A1-L1-B1 I-A and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein A1, B1, and L1 are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I-A for use to treat a condition or disorder responsive to degradation of MDM2 protein such as cancer.