Trispecific and/or trivalent binding proteins

US11192960B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Zhi-yong Yang · Potomac, US
• Gary J. Nabel · Cambridge, US
• Lan Wu · Bound Brook, US
• Edward SEUNG · Cambridge, US
• Ronnie Wei · Weston, US
• Jochen BENINGA · Frankfurt am Main, DE
• Ercole Rao · Frankfurt am Main, DE
• Wulf-Dirk Leuschner · Frankfurt am Main, DE
• Christian Beil · Frankfurt am Main, DE
• Christian Lange · Frankfurt am Main, DE
• Carsten Corvey · Frankfurt am Main, DE

Key dates

• Filing date: Nov 16, 2020
• Grant date: Dec 7, 2021
• Expiry date: Nov 16, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.