Aminopyrimidinyl compounds

US11197867B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• Andrew Fensome · Wayne, US
• Ariamala Gopalsamy · Lexington, US
• Brian Stephen Gerstenberger · Brookline, US
• Ivan Viktorovich Efremov · Sharon, US
• Zhao-Kui Wan · Lexington, US
• Betsy Susan Pierce · Kalamazoo, US
• Jean-Baptiste Telliez · Lexington, US
• John I. Trujillo · Ledyard, US
• Liying Zhang · Groton, US
• Li Xing · Lexington, US
• Eddine Saiah · Brookline, US

Key dates

• Filing date: Jul 2, 2020
• Grant date: Dec 14, 2021
• Expiry date: Jul 2, 2040

Classification

• Technology area (CPC H): Electricity
• CPC primary: H04N7/188
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound compound having the structure: or a pharmaceutically acceptable salt thereof, wherein X is N or CR, where R is hydrogen, deuterium, C1-C4 alkyl, C1-C4 alkoxy, C3-C6 cycloalkyl, aryl, heteroaryl, aryl(C1-C6 alkyl), CN, amino, alkylamino, dialkylamino, CF3, or hydroxyl; A is selected from the group consisting of a bond, C═O, —SO2—, —(C═O)NR0—, and —(CRaRb)q—, where R0 is H or C1-C4 alkyl, and Ra and Rb are independently hydrogen, deuterium, C1-C6 alkyl, C3-C6 cycloalkyl, aryl, aryl(C1-C6 alkyl), heteroaryl, (C1-C6 alkyl)heteroaryl, etc.; A′ is selected from the group consisting of a bond, C═O, —SO2—, —(C═O)NR0′, —NR0′(C═O)—, and —(CRa′Rb′)q—, where R0′ is H or C1-C4 alkyl, and Ra′ and Rb′ are independently hydrogen, deuterium, C1-C6 alkyl, C3-C6 cycloalkyl, aryl, aryl(C1-C6 alkyl), heteroaryl, (C1-C6 alkyl)heteroaryl, heteroaryl(C1-C6 alkyl), and heterocyclic(C1-C6 alkyl); Z is —(CH2)h— or a bond, where one or more methylene units are optionally substituted by one or more C1-C3 alkyl, CN, OH, methoxy, or halo, and where said alkyl may be substituted by one or more fluorine atoms; R1 and R1′ are independently selected from the group consisting of hydrogen, deuterium, C1-C4 …