Compositions and methods of mechanically inducing tissue regeneration

US11197944B2 · kind B2 · utility

Assignees

• President and Fellows of Harvard College · US
• CHARITÉ—UNIVERSITÄTSMEDIZIN BERLIN · DE

Inventors

• Christine Cezar · Sammamish, US
• Conor J. Walsh · Corning, US
• David J. Mooney · Ann Arbor, US
• Ellen T. Roche · Cambridge, US
• Herman H. Vandenburgh · Barrington, US
• Georg Duda · Berlin, DE

Key dates

• Filing date: Nov 18, 2016
• Grant date: Dec 14, 2021
• Expiry date: Mar 8, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides methods and compositions for promoting regeneration of a tissue, methods for preventing or reducing inflammation of a tissue, methods for preventing or reducing fibrosis of a tissue, methods for increasing a mass of a tissue, methods for increasing a level of oxygen available to a tissue, methods for increasing a rate of metabolic waste removal from a tissue, methods for increasing blood perfusion to a tissue, and methods of treating severe muscle tissue damage in a subject in need thereof by contacting the tissue with a composition that is suitable for applying cyclic mechanical compression to the tissue.