Thermoresponsive hydrogel

US11197948B2 · kind B2 · utility

Assignee

• UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG · ZA

Inventors

• Yahya Essop Choonara · Lenasia, ZA
• Pierre Pavan Demarco Kondiah · Randburg, ZA
• Pariksha Jolene Kondiah · Johannesburg, ZA
• Pradeep Kumar · Johannesburg, ZA
• Lisa Claire Du Toit · Randburg, ZA
• Thashree Marimuthu · Johannesburg, ZA
• Viness Pillay · Sandton, ZA

Key dates

• Filing date: Jan 31, 2018
• Grant date: Dec 14, 2021
• Expiry date: Dec 7, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08J2367/06
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

This invention relates to thermoresponsive hydrogels. Particularly, the invention relates to a thermoresponsive hydrogel comprising copolymer polyethylene glycol (PEG)-polycaprolactone (PCL)-polyethylene glycol (PEG) and polypropylene fumerate (PPF). The thermoresponsive hydrogel may further comprise a poloxamer, particularly Pluronic F-127. The invention extends to a method of manufacturing thermoresponsive hydrogels, also extends to an ink for a three dimensional (3D) printer including the thermoresponsive hydrogels. The invention further extends to a thermoresponsive hydrogel for use in the treatment of a bone injury and/or a bone defect, and/or to a method of treating a bone injury and/or a bone defect. The thermoresponsive hydrogels may include dispersed therein an active pharmaceutical ingredient (API), preferably an API falling in the Biopharmaceutics Classification System (BCS) class II, further preferably a statin type drug, most preferably simvastatin.