Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof

US11198697B1 · kind B1 · utility

Assignee

• Abb Vie Inc. · US

Inventors

• Ayman Allian · Grayslake, US
• Jayanthy Jayanth · Buffalo Grove, US
• Mohamed-Eslam F. Mohamed · Gurnee, US
• Mathew M. Mulhern · Lake Villa, US
• Fredrik Lars Nordstrom · Ridgefield, US
• Ahmed A. Othman · Libertyville, US
• Michael J. Rozema · Kenosha, US
• Lakshmi Bhagavatula · Vernon Hills, US
• Patrick J. Marroum · Springfield, US
• Peter T. Mayer · Libertyville, US
• Ahmad Y. Sheikh · Lake Forest, US
• Thomas B. Borchardt · Kenosha, US
• Ben Klünder · Ludwigshafen, DE

Key dates

• Filing date: Apr 14, 2021
• Grant date: Dec 14, 2021
• Expiry date: Apr 14, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.