T cell-antigen coupler with Y177 mutation and methods of uses thereof
US11198737B2 · kind B2 · utility
8Cited by
8References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 16, 2021 |
| Grant date | Dec 14, 2021 |
| Priority date | — |
| Expiry date | Apr 16, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16043
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y177 mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.