Hydrolysis of ester bonds in amide crosslinked glycosaminoglycans

US11198765B2 · kind B2 · utility

Assignee

• Galderma Holding SA · CH

Inventors

• Johan Olsson · Bromma, SE
• Hotan MOJARRADI · Uppsala, SE

Key dates

• Filing date: Dec 28, 2016
• Grant date: Dec 14, 2021
• Expiry date: Dec 28, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08J2305/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of preparing a hydrogel product comprising crosslinked glycosaminoglycan molecules, said method including: i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans include ester crosslinks formed as byproducts during the amide crosslinking; and ii) subjecting the crosslinked glycosaminoglycans to alkaline treatment to hydrolyze ester crosslinks formed as byproducts during the amide crosslinking.