System, method, and apparatus facilitating automated modular manufacture of cell therapy

US11198845B2 · kind B2 · utility

Assignee

• MULTIPLY LABS INC. · US

Inventors

• Federico Parietti · San Francisco, US
• Kameron C. Chan · San Francisco, US
• Alice Melocchi · Dalmine, IT
• Jeffrey Curhan · East Greenwich, US
• Michelle Chen · Berkeley, US
• Nolan Dickey · San Francisco, US
• Joaquin Giraldo-Laguna · San Francisco, US
• Roger Lo · San Francisco, US
• Lawrence Zachary Bright · San Francisco, US
• Sam Ihns · Cambridge, US
• Umberto Scarfogliero · San Carlos, US

Key dates

• Filing date: Apr 19, 2021
• Grant date: Dec 14, 2021
• Expiry date: Apr 19, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12M41/48
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A rigid cartridge for housing and removably coupling with a soft body bioreactor is provided. The rigid cartridge includes rigid walls defining a rigid housing. The rigid walls expose a fixed interior configured to house the soft body. An interior surface of a first rigid wall includes a first mating mechanism to engage a second mating mechanism of the soft body to removably coupled with the rigid cartridge and accommodate the soft body in the fixed interior of the rigid cartridge. A rigid wall includes a planar upper surface including an aperture. Each aperture is encompassed by an annular hood protruding upwardly from the substantially planar upper surface and integrally formed with the at least one rigid wall. The aperture is configured to receive and fixed engage a corresponding connector. Each connector includes a rigid coupling mechanism that provides communication with a corresponding plurality of ports of the soft body.