Microscale whole blood coagulation assay platform
US11199533B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 28, 2017 |
| Grant date | Dec 14, 2021 |
| Priority date | — |
| Expiry date | Aug 26, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01L1/2287
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A blood clot retraction assay device and methods of measuring whole-blood clot retractive forces during coagulation are described. When placed in proximity to a micro-beam, a blood droplet attaches thereto, applying a force to the micro-beam during clot formation. Using Piezoresistive micro-beams or other Piezoresistive components disposed upon such micro-beams, the device measures retractive force of a blood droplet based upon changes in resistance. The sensitivity of such measurements allows use of small quantities of blood for measurement, between 15 microliters and 300 microliters. The device further permits continuous measurement of coagulation, allowing measurement of distinct reaction, contraction development, and fibrinolysis phases for each blood sample.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.