Patent · US Active

Methylglyoxal-scavenging cyclic peptides and their use for the prevention and treatment of diseases associated with elevated methylglyoxal levels

US11202833B2 · kind B2 · utility

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9Claims

0Family size

Assignee

RUPRECHT - KARLS - UNIVERSITÄT HEIDELBERG · DE

Inventors

Sebastian BRINGS · Leimen, DE
Thomas FLEMING · Heidelberg, DE
Walter Mier · Bensheim, DE
Peter Nawroth · Leimen, DE

Key dates

Filing date	Nov 6, 2017
Grant date	Dec 21, 2021
Priority date	—
Expiry date	Feb 18, 2038

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to cyclic peptide compounds which inhibit or antagonize the binding of methylglyoxal (MG) and/or other reactive carbonyl species (RCS) to an arginine- or lysine-containing protein. Preferred scavenger compounds are said cyclic peptides comprising a specific amino acid motif and a hydrophobic modification, and pharmaceutical compositions thereof. The present invention furthermore relates to the use of the cyclic peptides as scavenger or antagonists of methylglyoxal and/or related reactive carbonyl species (RCS). The present invention furthermore relates to the use of the cyclic peptides for the prevention and/or treatment of a disease caused by or associated with methylglyoxal (MG) and/or reactive carbonyl species (RCS), in particular caused by or associated with elevated MG levels, such as diabetes and its associated complications, cardiovascular diseases and obesity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.